During the latest VitaDAO community call, the VitaFast team shared an exciting breakthrough in their autophagy research. Their initial lead compounds had already demonstrated a statistically significant improvement of 2-3 times greater autophagy induction compared to rapamycin.
Now, VitaFast’s newest compounds have shown even more promising results, exhibiting 10-100 times higher potency than their previous lead series! This increase in potency provides the team with considerable flexibility in optimizing dosage protocols to balance safety and maximize autophagy activation.
While these results need extensive further testing, they mark an important milestone in the project's mission to enhance autophagy - the natural process cells use to remove damaged components, which slows down as we age.
Project Lead Oliver, working with researchers at the University of Newcastle, presented their work on developing these compounds that could trigger cellular cleanup more effectively than current methods like fasting. Think of autophagy like your cell's recycling system: when it works well, your cells stay healthy longer.
These lab results are particularly interesting because rapamycin is considered a benchmark in aging research. However, it's important to note that these results are from early cell studies - the next crucial step is testing whether this improved performance holds up in living organisms.
What they've done so far:
- Found new compounds through careful screening and testing
- Developed lab tests to make sure the compounds work as intended
- Focused on making sure cells can complete the entire cleanup process
- Designed brand new, wholly owned, compounds to target the process
- Successfully showed their compounds can activate cellular cleanup in lab tests
What's coming next:
- Start testing compounds in worms (a common first step in aging research)
- Protect discoveries through patents
- Run more experiments to understand exactly how well these compounds work
- Test the compounds in different types of cells and organisms
The team is taking a careful, step-by-step approach to validate their findings. This matters because if successful, their work could lead to new ways to support healthy aging.
For VitaDAO members interested in the technical details: the team uses multiple testing methods including P62 clearance and LC3 assays, with special attention to lysosomal fusion in the autophagy process.
Watch the full update:https://x.com/i/broadcasts/1jMKgBODrNAxL (min 36+)
Learn more: https://vitafast.xyz
Join the community: https://t.me/fastvita
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